Brain against purple blue white background, slightly glowing effect.

Deep brain stimulation for movement disorders

Electrical stimulation of CNS cells in vitro and studies on the influence of electrical stimulation on inflammatory reactions of relevant CNS cells

Deep brain sti­mu­la­ti­on (DBS) is an estab­lished the­ra­peu­tic method for the sym­pto­ma­tic tre­at­ment of various move­ment disorders.

In this case, elec­tri­cal sti­mu­la­ti­on is used to inter­ve­ne in the com­plex motor con­trol cir­cuits away from the under­ly­ing patho­lo­gy. The cel­lu­lar mecha­nisms are still lar­ge­ly unex­plo­red here, in par­ti­cu­lar no in vitro stu­dies com­pa­ra­ble to DBS sti­mu­la­ti­on para­me­ters have been car­ri­ed out.

As part of this rese­arch pro­ject, a model for the elec­tri­cal sti­mu­la­ti­on of cells in the CNS is to be estab­lished, which is to be based on the com­mon cli­ni­cal sti­mu­la­ti­on para­me­ters. Mit die­sem Model soll der Ein­fluss der elek­tri­schen Sti­mu­la­ti­on auf das Ster­ben, die Pro­li­fe­ra­ti­on und das Che­mo­kin- und Zyto­kin­pro­fil rele­van­ter Zel­len des ZNS unter­sucht wer­den. Against the back­ground that inflamm­a­to­ry pro­ces­ses play a major role in many neu­ro­de­ge­nera­ti­ve dise­a­ses, the influence of elec­tri­cal sti­mu­la­ti­on under inflamm­a­to­ry con­di­ti­ons will also be inves­ti­ga­ted in fur­ther expe­ri­ments. For this pur­po­se, the cells are to be addi­tio­nal­ly incu­ba­ted with lipo­po­lys­ac­cha­ri­de and sub­se­quent­ly the con­tent of various inflamm­a­to­ry media­tors is to be deter­mi­ned. Sub­se­quent­ly, the influence of neu­ro­pro­tec­ti­ve and anti-inflamm­a­to­ry sub­s­tances such as tre­foil fac­tor 3 and ery­thro­poie­tin on the che­mo­ki­ne and cyto­ki­ne pro­fi­le under elec­tri­cal sti­mu­la­ti­on will be investigated.

In addi­ti­on to estab­li­shing a cli­ni­cal­ly rele­vant cell cul­tu­re model for elec­tri­cal sti­mu­la­ti­on, we hope to gain a bet­ter under­stan­ding of the cel­lu­lar pro­ces­ses invol­ved in DBS.

It is a col­la­bo­ra­ti­ve pro­ject bet­ween the Cli­nic for Neu­ro­sur­gery at UKSH, Cam­pus Kiel (Direc­tor: Prof. Dr. M. Syn­o­witz, Head of Rese­arch Labo­ra­to­ry: Prof. Dr. Dr. J. Held-Feindt) and the Insti­tu­te of Ana­to­my (Direc­tor: Prof. Dr. R. Luci­us). The pro­ject is fun­ded in part by the 2017 rese­arch grant from the medi­cal facul­ty of Kiel Uni­ver­si­ty. In 2019, the rese­arch pro­ject will also recei­ve fun­ding from the Meh­dorn Fami­ly Foundation.


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